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Metastability and Eye Movements: A Dynamical‑Systems Interpretation

  1. Why metastability is a natural language for gaze behavior The idea that perception, attention, and neural activity evolve through transiently stable states has deep roots in cognitive science and neuroscience. Concepts such as attractors , basins , noise‑induced transitions , and escape times appear in work on perceptual switching, decision‑making, and neural population dynamics (Kelso, 1995; Rabinovich et al., 2008; Deco & Jirsa, 2012). Eye movements, especially the alternation between fixations and saccades ,   fit remarkably well into this metastable picture. The Freidlin–Wentzell theory of rare events (Freidlin & Wentzell, 2012) provides a rigorous mathematical language for these intuitions. 2. Fixations as metastable states  Consider the gaze position X t as the state of a stochastic dynamical system. During a fixation the  gaze remains confined to a small region, microsaccades and noise generate small fluctuations, and the gaze tends to return...

Understanding Anaerobic Threshold (VT2) and VO2 Max in Endurance Training

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  Introduction: The Science Behind Ventilatory Thresholds VT1 vs. VT2: Defining Energy Transitions p (Aerobic Threshold) : The transition from lipid metawwwpp (fat-burning) to a mixed metabolism, where both carbohydrates and fats fuel muscle activity. V0T2 (Anaerobic Threshold) : The point where the  shifts to a predominantly carbohydrate-based wmetabolism , leading to rapid lactate waccumpulation and increased reliance on anaerobic energy pathways. www w In p VT1 and VT2 Wwww ewAgep & Sex Younger athletes generally exhibit higher VT2 values , while aging naturally reduces aerobicw capacity. Men tend to have a higher VO2 Max due to greater lung capacity and muscle mass, but women can achieve similar endurance levels through optimized training. Body Composition & Health Status High body fat percentage may reduce VT2 efficiency, as excess weight increases ...

R function: calculate the anaerobic threshold

RunTime <- function(Time,Distance,Distance_reference,bpm) { ## INPUT #Time: run time measured [min, s] #Distance: run distance [mt] #Distance_reference: reference distance [mt] of which we want to evaluate the expected time  #bpm: cardiac frequency (beats per minute)  ## OUTPUT # T2 = tempo corsa atteso su distanza di riferimento (s) # V2 = velocità attesa su distanza di riferimento (km / h) # V1 = velocità media singole corse (km / h) # Vm = velocità media su distanze e tempi rilevati cumulati (km / h) # FC = Frequenza cardiaca per minuto # SAN = Soglia Anaerobica stimata # SAN2 = proiezione Soglia Anaerobica su tempi attesi e distanza di riferimento # D1 = distanze percorse # P1 = passo corsa per km [min, s]   # P2 = passo corsa atteso per km [min, s]   T1 <- Time D1 <- Distance D2 <- Distance_reference T = T1[,2] + T1[,1]*60 # run time (seconds) T2 = T* (D2/D1)^(1.06) # expected time (seconds) V2 = 3.6 * (D2/T2) V1 = 3.6 * (D1/T); p = (1000*T...

Design and validation of a semi-quantitative microneutralization assay for human Metapneumovirus A1 and B1 subtypes

This study presents a comprehensive overview of human Metapneumovirus (hMPV), an enveloped RNA virus identified in 2001. It details the virus's biological characteristics, epidemiological significance, and ongoing vaccine research efforts. hMPV is classified within the Pneumoviridae family and comprises two global genetic lineages, namely A and B. While the pathogenic mechanisms underlying hMPV infection remain inadequately understood, the structural proteins involved, particularly the Fusion (F) protein, are instrumental in mediating infection and modulating the immune response. The F protein is highly conserved and is regarded as the principal target for vaccine development, as it promotes the formation of neutralizing antibodies, a contrast to the more variable Glycoprotein G. From an epidemiological perspective, hMPV is widely distributed and predominantly impacts infants and young children, often resulting in severe respiratory illnesses. Despite the absence of a licensed va...

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